Background: Gram-negative pathogens, notably Klebsiella pneumoniae, pose a global challenge due to their propensity for multidrug resistance, particularly in nosocomial infections like urinary tract infections (UTIs). Antimicrobial stewardship programs (ASPs) have been instituted to address the rampant misuse of antibiotics, aiming to foster judicious prescribing practices. This study evaluates the impact of an ASP on antibiotic sensitivity patterns of K. pneumoniae in a tertiary care hospital in Central India. Methods: Urine samples positive for K. pneumoniae collected during 2023 and 2024 were subjected to antimicrobial susceptibility testing. Results: Results demonstrate significant improvements in sensitivity patterns, notably in carbapenems and chloramphenicol. These findings underscore the effectiveness of ASPs in guiding antibiotic prescribing practices, attributed to enhanced acceptance among healthcare professionals. Conclusion: Sustained initiatives to encourage responsible antibiotic utilization and garner support from healthcare professionals remain crucial in effectively tackling antibiotic resistance. Additionally, further research is needed to assess the long-term viability and scalability of such interventions.
