This extensive study delves into the many facets of Annona senegalensis, a plant species that has been well-respected in traditional African medicine and is now gaining attention in modern pharmacology. The review takes a methodical look at four main areas: pharmacological characteristics, phytochemical profile, geographical distribution and ecological environment, and ethnomedical uses. The medicinal properties of Annona senegalensis have earned it a place of adoration in many African traditions. According to historical records, it was used to cure a wide variety of illnesses, including fevers, skin problems, gastrointestinal problems, and malaria. The tapestry of indigenous medicine and culture highlights the plant's centrality to traditional healing practices. The assessment emphasises the plant's widespread presence throughout many African biomes, demonstrating its capacity to adapt to different ecological circumstances, in terms of dispersion. This review also examines the environmental conditions important for its growth, providing a better knowledge of its ecological niche and possible vulnerabilities in the face of environmental changes. The phytochemical examination of A. senegalensis reveals a broad array of bioactive chemicals, including but not limited to alkaloids, flavonoids, saponins, and terpenes. These elements are painstakingly connected with their unique therapeutic potentials, revealing insights into the metabolic underpinnings of the plant's medicinal characteristics. Finally, the review synthesizes a range of pharmacological research that evaluate the effectiveness of A. senegalensis in diverse medicinal applications. Notable results include its antibacterial, anti-inflammatory, antiparasitic, and anticancer effects, which are critically studied in light of modern scientific methodology and therapeutic significance. This review not only articulates the historic and contemporary relevance of the plant but also acts as a springboard for future research initiatives. It underlines the need for greater study into its latent potential, notably in drug discovery and development, while also increasing awareness about the protection of this unique species in its native environment
Annona senegalensis, ethnomedicine, phytochemistry, pharmacological activities, toxicity
Adayat, S. I., Samira, A., & Musliu, A. (2014). Extraction and phytochemical screening of the root and leaves of Annona senegalensis (Wild custard apple). Academic Journal of Interdisciplinary Studies, 3 (7), 9-15.
Adesogan, E. F, & Durodola, J. I (1976). Antitumor and antibiotic principles of Annona senegalensis. Phytochemistry, 15, 1311-1312.
Adisa, R. A., Kolawole, N., Suleiman, I. A., et al. (2019). Alteration of antioxidant status and mitochondrial succinate dehydrogenase activity in the liver of Wistar strain albino rats treated with ethanol extracts of Annona senegalensis Pers (Annonaceae) stem bark. Toxicology Research, 35, 13-24.
Adjakpa, J. B., Ahoton, L. E., Obosson, F. H., et al. (2016). Ethnobotanical study of Senegal custard apple (Annona senegalensis) in Dasa-Zoume township, Republic of Benin. International Journal of Biological and Chemical Sciences. 10 (5), 2123-2137.
Adzu, B., Amos S., Adamu, M., & Gamaniel, K. (2003). Anti-nociceptive and ant-inflammatory effects of the methanol extract of Annona senegalensis root bark. Journal of Natural Remedies, 3, 63-67.
Afolabi, F., & Afolabi, O. (2013). Phytochemical Constituents of Some Medicinal Plants in South West, Nigeria. IOSR Journal of Applied Chemistry, 4(1),76-78.
Ahmed, A, Bassem, S.M., Mohamed. Y, et al. (2010). Cytotoxic essential oil from Annona senegalensis Pers leaves. Pharmacognosy Research, 2, 211-214.
Ahombo, G., Ampa. R., Diatewa, M., et al. (2012). Investigating on related diabetes therapeutic plants used in traditional medicine at Brazzaville. Journal of Medicinal Plant Research. 6(44), 5630-5639.
Aiyeloja, A. A, & Bello, O. A. (2006). Ethnobotanical potentials of common herbs in Nigeria: A case study of Enugu State, Educational Research and Reviews, 1(1),16-22.
Ajaiyeoba, E., Abiodun, O., Falade, M., et al. (2006a). In vitro cytotoxicity studies of 20 plants used in Nigerian antimalarial ethnomedicine. Phytomedicine, 13, 295-298.
Ajaiyeoba, E., Falade, M., Ogbole, O., et al. (2006b). In vivo antimalarial and cytotoxic properties of Annona senegalensis extract. African Journal of Traditional, Complementary and Alternative Medicine, 3(1), 137-141.
Ajboye, T., Yakubu, M., Salau, A., et al. (2010). Antioxidant and drug detoxification potential of aqueous extract of Annona senegalensis leaves in carbon tetrachloride-induced hepatocellular damage. Pharmaceutical Biology, 48(12), 136-170.
Alawa, C., Adamu, A., Gefu, J., et al. (2003). In vitro screening of two Nigerian medicinal plants (Vernonia amygdalina and Annona senegalensis) for anthelmintic activity. Veterinary Parasitology, 113(1). 73-81.
Ameen, A., Usman, L., Oganija, F., et al. (2011). Chemical composition of leaf essential oil Annona senegalensis Pers (Annonaceae) growing in North Central Nigeria. International Journal of Biological and Chemical Sciences, 5 (1), 375-379.
Amlabu, E., Ajagun, E., & Wandayi, A., et al. (2014). Detoxification of Echis ocellatus venom induced toxicity by Annona senegalensis Pers. Journal of Complementary and Integrative Medicine, 11(2), 93-97.
Arnold, K. J., & Gulumain, M. Pharmacopea of traditional medicine in Venda. Journal of Ethnopharmacology, 12, 35-74.
Atawodi, S., Bulus, T., Ibrahim, S., et al. (2003). In vitro trypanocidal effect of methanolic extract of some Nigerian Savannah plants. African Journal of Biotechnology, 2(9), 317-321.
Atawodi, S. (2005). Comparative in vitro trypanocidal activities of petroleum ether, chloroform, methanol and aqueous extracts of some Nigerian Savannah plants. African. Journal of Biotechnology, 4(2), 177-182.
Attiq, A., Jalil, J., & Husain, R. (2017). Annonaceae: Breaking the wall of inflammation. Frontiers in Pharmacology, 8, 752.
Awa, E., Ibrahim, S., & Ameh, D. (2012). In-vitro evaluation of antibacterial activity of crude extract from the stem bark of Annona senegalensis Pers. International Journal of Pharmaceutical Sciences and Research, 3(4),1128-1132.
Bamba, P. O., Abalansard, G., Maillard, G.et al, (1984). Characterization of amino acids in the stem bark of Annona senegalensis Pers. Plante Midicinales Phytotherapie, 18, 36-45.
Bassam, S. M., Kazman, A. I., Harnett, T. E., et al. (2022). Traditional uses, phytochemistry and pharmacological activities of Annonaceae. Molecules, 27,3462.
Chhabra, S. C., Mahunnah, R. L. A., Mshiu, E. N. (1987). Plants used in traditional medicine in Eastern Tanzania,1. Pteridophytes,and Angiosperms (Aquanthageae to Canelliiceae). Journal of Ethnopharmacology, 21, 253-277.
Dalziej, J. M. (1937). The useful plants of West Tropical Africa. Crown Overseas Agents for the Colonies, London, 2-3
Dandjesso, C., Klotoé, J., Dougnon, T., et al. (2012). Phytochemistry and hemostatic properties of some medicinal plants sold as anti-hemorrhagic in Cotonou markets (Benin). Indian Journal of Science and Technology, 5(8), 3105-3109.
Djoza, R. D., Ashande, C. M., & Mpiana, P. T. ((2017). A mini-review on the pharmacognosy and phytochemistry of a tropical medicinal plant Annona senegalensis Pers (Annonaceae). Tropical Plant Research, 4, 168-175.
Dholvitayakun, A., Trachoo, N., & Sakee, U. (2013). Potential application of Annon senegalensis leaf extract in the treatment and prevention of foodborne bacterial disease. Natural Product Communication, 8 (3), 385-388.
Dongmo. N. M., Fokunang, C., Fekam, B. F., et al. (2014). Anticonvulsant activity of extracts from six Cameroonian plants traditionally used to treat epilepsy. International Journal of Biological and Chemical Sciences, 8(6),2407-2415.
Faleyimu, O., Ahmad, I., & Akinyemi, O. (2010). Herbal approach to the treatment of Chicken pox: A case study of Giwa Local Government, Kaduna State. Nigeria. International. Journal of Biomedical and Health Sciences, 6(1), 13-18.
Faleyimu, O., & Akinyemi, O. (2010). Herbal approaches to the problem of erectile dysfunction in Kaduna State, Nigeria. Egyptian Journal of Biology, 12, 103-107.
Fall, D., Sambou, B., Seck, M., et al (2008). Enhancing the anthelminthic activity roots of Annona senegalensis. Dakar Medica, 53(1), 61-67.
Gueye, S., Diop, M. T., Seck, D., et al. (2011). Biochemical fractions activity of Annona senegalensis Pers. extract leaves to protect groundnut against the seed-beetle Caryedon serratus OL. (Coleoptera, Chrysomelidea, Bruchinae). International Journal of Plant, Animal and Environmental Sciences, 1(2),122-130
Igoli, J., Ogaji, O., Tor-Anyin, T., et al. (2005). Traditional medicine practice amongst the Igede People of Nigeria. Part II. African. Journal of Traditional, Complementary and Alternative Medicine, 2(2),134-152.
Ijaiya, I., Arzika, S., & Abdulkadir, M. (2014). Extraction and phytochemical screening of the root and leaves of Annona senegalensis (Wild Custad Apple). Academic. Journal of Interdisciplinary Studies, 3(7), 9-15.
Igweh, A., & Onabanjo, A. (1989) Chemotherapeutic effects of Annona senegalensis in Trypanosoma brucei brucei. Annals of Tropical Medicine and Parasitology, 83(5), 527-534.
Ilboudo, S., Ouedraogo. G. G., Ouedraogo, S., et al. (2019). Phytochemical, acute and subacutetoxicity studies of Annona senegalensis Pers (Annonaceae) root wood extracts. African Journal of Biochemistry Research, 13, 44-55.
Jada, M. S., Usman, W. A., & Adamu, Y. (2014). In vitro antimicrobial effect of crude tannins isolated from the leaf of Annona senegalensis. International Journal of Biochemical Research and Review, 4(6), 615-623.
Jada, M. S., Usman, W. A., & Olabisi, A. O. (2015). Crude flavonoids Isolated from the stem bark of Annona senegalensis have antimicrobial activity. Journal of Advances in Biology and Biotechnology, 2(1),24-29.
Kabiru, A. Y., Salako, A. A., & Ogbadoyi, E. O. (2010). Therapeutic effects of Annona senegalensis Pers stem bark extracts in experimental African Trypanosomiasis. International Journal of Health Research, 3(1), 45-49.
Khallouki, F., Younos, C., Soulimani, R, et al. (2002). Chemical composition of the essential oils of Annona cuneata L. and Annona senegalensis Pers. stem barks. Flavour Fragrance Journal, 17(5), 398-400.
Kitadi, J.M., Inkoto, C. L., & Lengbiye, E. M. (2020). Mineral content and antisickling activity of Annona senegalensis, Alchornea cordifolia, and Vigna unguiculataused in the management of sickle cell disease in the Kwilu Province (Congo DR). International Blood Research and Review, 11 (3), 18-27.
Klaus, V., & Adala, H. S. (1994). Traditional herbal eye medicine in Kenya. World Health Forum, 15, 138-143.
Koggie, A, Z., Ihuma, J. O.,, Nyikwagh, P. H. (2022). Antibacterial activities of Annona senegslensis Pers (Annonaceae) extracts on Eschericia coli, Proteus mirabilis and Klebsiela pneumonia .Asian Journal of Biology, 14(2), 35-41.
Konate A, Sawadogo W, Dubruc F, et al. (2012). Phytochemical and anticonvulsant properties of Annona senegalensis Pers. (Annonaceae), Plant used in Burkina folk medicine to treat epilepsy and convulsions. British Journal of Pharmacology and Toxicology, 3(5), 245-250.
Konaté, K., Sanou, A., Aworet-Samseny, R. R., Benkhalti, F., Sytar, O., Brestic, M., ... & Dicko, M. H. (2021). Safety profile, in vitro anti-inflammatory activity, and in vivo antiulcerogenic potential of root barks from Annona senegalensis Pers.(Annonaceae). Evidence-based Complementary and Alternative Medicine, 2021. doi: 10.1155/2021/4441375.
Lall, N., Kishore, N., Bodiba, D, et al., et al. (2017). Alkaloids from aerial parts of Annona senegalensis against Streptococcus mutans. Plant Product Research, 37, 1944-1947.
Lame, Y., Nukenine, E., Pierre, D., et al. (2014). Larvicidal activity of Annona senegalensis and Boswellia dalzielii leaf fractions against Aedes aegypti (Diptera: Culicidae). International Journal of Mosquito Research, 1(4), 25-29.
Lawal, A., Ajiboye, J., & Berinyuy, E,B. (2021). Chemical composition, toxicology, ethno-medicinal and pharmacological reports of Annona senegalensis: A review. Journal of Drug Discovery, Development and Delivery, 7 (1), 1038.
Li, H. T., Wu, H. M., Chen, H. L., et al. (2013). The pharmacological activities of (-) anonine. Molecules, 18 (7), 8257.
Mackie, A., & Misra, A. L., (1956). Chemichal investigation of the leaves of Annona senegalensis 1: Constituents of the leaf wax. Journal of Science, Food and Agriculture, 7, 203
Mackie, A., & Ghatee, N. (1958). Leaves of Annona senegalensis11. Carbohydrates,glycoside, proteins, amino acids,sterols. Journal of Science, Food and Agriculture, 9, 88.
Magadula, J., Innocent, E., Mbwambo, Z. et al. (2014). Phytochemical and pharmacological studies of some medicinal plants from Tanzania. International Journal of Current Research and Academic Review; 2(10), 99-111.
Magadula, J., Innocent, E., & Otieno, J. (2009). Mosquito larvicidal and cytotoxic activities of 3 Annona species and isolation of active principles. Journal of Medicinal Plant Research, 3(9), 674-680.
Magassouba, F., Diallo, A., Kouyat´e, M. et al. (2007). Ethnobotanical survey and antibacterial activity of some plants used in Guinean Traditional Medicine. Journal of Ethnopharmacology, 114(1), 44-53.
Mann, A., Ibrahim, K., Oyewale, A. et al. (2009). Antimycobacterial activity of some medicinal plants in Niger State, Nigeria. African. Journal of Infectious Disease, 3(2), 44-48.
Mbayo, Y., Bobbo, A., Barkindo, A., et al. (2023). Effects of ethanolic leaf extract of Annona senegalensis on semen of albino rats. British Journal of Multidisciplinary and Advanced Studies, 4 (4), 1-14.
Moghadamtousi, S., Fadaeinasab, M., Nikzad, S. et al. (2015). Annona muricata (Annonaceae): A review of its traditional uses, isolated acetogenins and biological activities. International Journal of Molecular Sciences, 16, 15625-15658.
More, G., Tshikalange, T., Lall, N., et al. (2008). Antimicrobial activity of medicinal plants against oral microorganisms. Journal of Ethnopharmacology, 119(3), 473- 477.
Mpiana,, P. (2012), Antisickling properties, thermal and photochemical degradations of anthocyanin extracts from Annona senegalensis (Annonaceae) International . Journal of Biological and Chemical Sciences, 6(5), 2241-2251.
Mukungulu, G., Tshilanda, D., Tshibangu, D., et al. (2015). Larvicidal activity of some Congolese plant extracts against Anopheles gambiae. Journal of Advancement in Medical and Life Sciences, 3(2), 1-4.
Musa, D. D., Anakaa, T. M., & Bashir, K. A. (2017). Phytochemical analysis of crude extracts from Annona senegalensis and its anti-snake venom potentials on Albino rats. Fudma Journal of Sciences, 1 (1), 139-142.
Mustapha, A., Owuna, G., & Uthman, I. (2013). Plant remedies practiced by Keffi People in the management of dermatosis. Journal of Medicinal Plant Studies, 1(5), 112-118.
Mustapha, A. A., (2013). Annona senegalensis Persoon: A multipurpose shrub, its phytotherapeutic, phytopharmacological and phytomedicinal Uses. International Journal of Science and Technology, 2(12), 862-865.
Mustapha, A. A. (2014). Ethnobotanical field survey of medicinal plants used by traditional medicine practitioners to manage HIV/AIDS opportunistic infections and their prophylaxis in Keffi Metropolis, Nigeria. Asian Journal of Plant Science and Research, 4(1), 7-14.
Ngamo, T., Ngatanko, I., Ngassoum, M. et al. (2007). Persistence of insecticidal activities of crude essential oils of three aromatic plants towards four major stored product insect pests. African Journal of Agricultural Research, 2(4), 173-177.
Ngbolua, K., Mudogo, V., Mpiana, P., et al. (2014). In vito and in vivo anti-malarial and cytotoxic activities of ethanolic extracts of Annona senegalensis Pers (Annonaceae) from Democratic Republic of the Congo. Journal of Modern Drug Discovery and Drug Delivery Research, 2, 1-5.
Nukenine, E., Monglo, D., Musongong, G. et al (2006). Evaluation of anthelminthic potential of ethanolic plant extracts from Northern Cameroon against eggs and infective larvae of Haemonchus concortus. Journal of Biological Sciences, 6(2), 426-433.
Nwonuma, C., Irokanulo, E., Jolaiya, A. et al, (2015). Effect of aqueous leaf extract of Annona senegalensis on selected testicular function indices of Wistar rats. America. Journal of Life Sciences, 3(3), 203-212.
Odoh, U, Ezugwu C & Ajali U. (2004). Preliminary investigation of the analgesic activity of the chloroform root extract of Annona senegalensis. Journal of Pharmaceutical and Allied Sciences, 2, 169-172.
Ofukwu, R., Ayoola, A., & Akwuobu, C. (2008). Medicinal plants used in the management of tuberculosis in humans and animals by Idoma tribe of North Central Nigeria, Nigerian. Veterinary Journal, 29(2), 25-30.
Ogbadoyi, E., Abdulganiy, A., Adama, T. et al (2007). In vivo trypanocidal activity of Annona senegalensis Pers. leaf extract against Trypanosoma brucei. Journal of Ethnopharmacology, 112(1), 85-89.
Ogoli, J., Tsenongo, S., Tor-Anyin, T. (2011). A Survey of antivenomous, toxic and other plants used in some parts of Tivland, Nigeria. International of Journal Medicinal and Aromatic Plant, 1(3), 240- 244.
Okhale, S. E., Akpan, E., Fatokun, O. T., et al. (2016). Annona senegalensis Persson (Annonaceae): A review of its ethnopharmacological uses. biological and phytocompounds. Journal of Pharmacognosy and Phytochemistry, 5 (2), 211-219.
Omeke, C. P., Udodeme, H. O., Nwafor, H. I., et al. (2019). Antioxidant and hepatoprotective properties from the extract and fractions of Annona senegalensis Pers (Annonaceae) stem bark grown in Nigeria. European Journal of Medicinal Plants, 28 (4), 1-13.
Okoli, C., Onyeto, C., Akpa, B. et al. (2010). Neuropharmacological evaluation of Annona senegalensis leaves. African Journal of Biotechnology, 9(49), 8435- 8444.
Okoye, T., Akah, P., Okoli, C. et al. (2012). Antimicrobial effects of a lipophilic fraction and kaurenoic acid isolated from the root bark extracts of Annona senegalensis. Evidence-Based Complementary and Alternative Medicine, Article ID, 2012, 831327
Okoye, T., Akah, P., Omeje, E., et al. (2013). Anticonvulsant effect of kaurenoic acid isolated from the root bark of Annona senegalensis. Pharmacology, Biochemistry and Behaviour, 109, 38-43.
Oladele, G., Faramade, I., & Ogunbodede, M. (2014). Effect of aqueous extract of Annona senegalensis leaves on the spermiogram of male albino rats. World Journal of Pharmacy Pharmaceutical Sciences, 3(8),409-418.
Orwa, C., Mutua, A., Kindt, R., et al. (2009). Agroforestree Database: A Tree Reference and Selection Guide Version 4.0,
Otimenyin, S., Omeri, F. (2014). Hypnotic effect of methanolic extracts of Annona senegalensis bark and Ficus thonningii leaves in mice and chicks. International Journal of Pharmacy and Pharmaceutical Research, 1(1), 1-12.
Philipov, S., Kande, K. M., & Mahev, K. (1995). Alkaloids of Annona senegalensis. Fitoterapia, 66, 275-276.
Price. K., Johnson, R., & Frederick, H. (1987). The chemical and biological significant of saponins in food and feeding stuffs. Critical Ravager in Food Science and Nutrition, 28, 135.
Potchoo, Y., Guissou, I., Lompo, M., (2008). Antioxidant activity of aqueous methanol and ethyl acetate extract of leaves of Annona senegalensis Pers. from Togo versus the one originates from Burkina Faso. International Journal of Pharmacology, 1(1), 1-5.
Sahpaz, S., Carmen G. M., Hocquemiller, R. et al. (1996). Annosenegalin and annogalene: two cytotoxic monotetrahydrofuran acetogenins from Annona senegalensis and Annona cherimolia. Phytochemistry, 42(1), 103-107.
Sahpaz, S., Bories,, C., Loiseau, P., et al. (1994). Cytotoxic and antiparasitic activity from Annona senegalensis seeds. Planta Medica, 60, 538-540.
Setzer, W., Ogungbe, I. (2012). In-silico investigation of antitrypanosomal phytochemicals from Nigerian medicinal plants. PLoS Neglected Tropical Diseases, 6(7), e1727.
Suleiman, M. M., Dzenda, T., & Sani, C. A. (2008). Antidiarrhoeal activity of the methanol stem bark extract of Annona senegalensis Pers (Annonaceae). Journal of Ethnopharmacology, 116(1), 125-130.
Suleiman, M., Mamman, M., Igomu, E., et al. (2014). Evaluation of analgesic and anti-inflammatory effects of the crude methanol extract of the stem-bark of Annona senegalensis Pers. International Journal of Medicinal and Aromatic Plants, 4(2), 88-96.
Tamfu,, A. N., Fotsing, M. T., & Talla, E. (2021). Bioactive constituents from seeds of Annona senegalensis Persoon (Annonaceae). Natural Product Research, 35 (10), doi: 10.1080/14786419.1634713.
Traore, M. S., Baldé, M. A., Diallo, M. S.,et al. (2013). Ethnobotanical survey on medicinal plants used by Guinean traditional healers in the treatment of malaria. Journal Ethnopharmacology, 150(3), 1145-1153
Yeo, D., Dinica, R., Yapi, H., et al. (2011). Evaluation of the anti-inflammatory activity and phytochemical screening of Annona senegalensis leaves. Therapie, 66(1), 73-80.
Yisa, J., Egila, J., & Darlinton, A. (2010). Chemical composition of Annona senegalensis from Nupe land, Nigeria. African. Journal of Biotechnology, 9(26), 4106-4109.
You, M., Wickramaratne, D., Silva, G. et al. (1995). (‐)‐Roemerine, an aporphine alkaloid from Annona senegalensis that reverses the multidrug‐resistance phenotype with cultured cells. Journal of Natural Product, 58(4), 598-604.
Youan, B., Coulibaly, S., Miezan, T., et al (1997). In vivo evaluation of sixteen plant extracts on mice inoculated with Trypanosoma brucei gambiense. Bulletin of World Health Organization, 75(4), 343-348.